Hepatic Biospecimens
Prospective human hepatic biospecimens for use in research applications.
High-quality human hepatic tissues
LifeNet Health® LifeSciences recovers high-quality human hepatic biospecimens for research and adheres to the highest standards of ethical and safe tissue recovery.
We partner with researchers to ensure proper storage, handling, and shipping of the biospecimen to preserve its integrity for dependable, reproducible, and biologically relevant liver research findings.
Research solutions
LifeNet Health® LifeSciences offers researchers unmatched access to donated human liver biospecimens as whole gifts, tissue samples, and primary cells.
Tissue samples for every fibrotic stage
Donated human liver biospecimens are available from normal (healthy) donors and donors with medical conditions (i.e., MASH or cirrhosis).
Liver tissue samples spanning the MASLD/MASH/Fibrosis spectrum are available.
Each sample includes a comprehensive donor medical and social history report and a detailed histopathology assessment including MASLD activity score (MAS) and fibrosis stage.
We offer biospecimens with MAS scores of 0-6 and fibrosis stages 0-4.
Chaim, F.D.M., et al. Sci Rep 10, 8496 (2020).
Features
- Tissues are prospectively recovered from donors with known demographics, including age, sex, BMI, ethnicity, cause of death, and social medical history.
- Fresh, snap-frozen, cryopreserved, and FFPE liver tissue samples available.
- Hematoxylin and Eosin (H & E) staining available.
Benefits
- Our entire process - from recovery of human tissue to storage and shipping - is designed to preserve tissue integrity.
- Using tissue from carefully selected human donors ensures that confounding variables, such as underlying medical conditions or medication use, does not affect research results.
- Low interval from death to preservation.
- Quick delivery available upon request.
Donor-matched companion cells
Donor-matched snap-frozen and FFPE liver tissue samples are available with select primary liver cells, enabling researchers to pair tissue-based analysis with complementary in vitro studies using cells from the same donor.
- Primary human hepatocytes
- Kupffer cells
- Stellate cells
- Liver endothelial cells
TruVivo®
2D+ hepatic system
TruVivo® is the first and only in vitro 2D+ hepatic system to provide human-relevant, reliable results in an easy-to-use format, empowering ADME/DMPK, toxicology, and disease modeling applications.
Supporting research
into drug metabolism
and liver disease
Drug-drug interactions
Pharmacogenomics studies
Transporter assays
Metabolic clearance
2D & 3D cell culture
Disease modeling
Toxicity studies
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Cirrhosis
Wilson’s Disease
Liver cancers
Hepatitis
Learn more about working with LifeNet Health LifeSciences
“The solid organs we have received from LifeNet Health were procured in such a fashion that my team was easily able to prep the samples for our laboratory perfusion studies.“
“We continue to be updated on the progress of our projects, and the communication is consistent and timely. The customer service is amazing.”
“Our project was fulfilled within the expected timeline and the LifeNet Health team was gracious to work with us collaboratively to address our challenging delivery schedule.”
Resources
Human Biospecimens for Research
Dose-response in a high density three-dimensional liver device with real-time bioenergetic and metabolic flux quantification
