Reliable Metabolic Stability Assessment of Low-Clearance Compounds
Drug developers rely on in vitro hepatic models to evaluate metabolic stability and predict human clearance of compounds, but many standard hepatocyte models fail to maintain metabolic activity and cellular architecture long enough to support extended exposure studies.
TruVivo supports prolonged exposure studies for more accurate clearance predictions of metabolically stable compounds in addition to:
- Aldehyde oxidase substrate evaluation
- Clearance predictions across a broader range of chemotypes
- IVIVE and PBPK modeling
- Mechanistic metabolism and DMPK studies
Dive into the data and see how TruVivo provides:
- Extended metabolic stability to support quantitative assessment of low-clearance compounds
- More accurate prediction of human hepatic clearance compared to standard 4-hour suspension hepatocyte (SH) assays
- Minimal donor noise for reduced donor-to-donor variability
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